Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 7/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.47 |
| ▸ | MMP1 | P03956 | 6/20 | 0.41 |
| ▸ | MMP3 | P08254 | 6/20 | 0.41 |
| ▸ | MMP7 | P09237 | 5/20 | 0.41 |
| ▸ | MMP13 | P45452 | 5/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984819 | 0.85 | ADRB3 (0.65) | ADRB3ADRB1ADRB2MMP1MMP3 | |
| SCHEMBL6985800 | 0.76 | ADRB3 (0.79) | ADRB3ADRB1ADRB2MMP1MMP3 | |
| SCHEMBL6985805 | 0.76 | ADRB3 (0.79) | ADRB3ADRB1ADRB2MMP1MMP3 | |
| SCHEMBL6987545 | 0.72 | HRH3 (0.43) | ADRB3ADRB1ADRB2LMNAMEN1 | |
| SCHEMBL6982931 | 0.70 | ADRB3 (0.82) | ADRB3ADRB1ADRB2CA1CA2 | |
| SCHEMBL6074513 | 0.70 | ADRB1 (0.54) | ADRB3ADRB1ADRB2MEN1MAPT | |
| SCHEMBL6988523 | 0.67 | ADRB3 (0.67) | ADRB3ADRB1ADRB2CA1CA2 | |
| SCHEMBL6982731 | 0.66 | ADRB3 (0.43) | ADRB3ADRB1ADRB2MMP1MMP3 | |
| SCHEMBL6074347 | 0.66 | ADRB3 (0.52) | ADRB3ADRB1ADRB2CA1CA2 | |
| SCHEMBL22187399 | 0.64 | CA12 (0.74) | MMP1MMP13CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1328512-A2 | CYCLYLAMINE SULFONAMIDES AS BETA-3 ADRENERGIC RECEPTOR AGONISTS | Wyeth (US) | 2003-07-23 | — | — | EP | disclosed |
| WO-2002006221-A2 | CYCLYLAMINE SULFONAMIDES AS BETA-3 ADRENERGIC RECEPTOR AGONISTS | WYETH (US) | 2002-01-24 | — | — | WO | disclosed |