Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | LTA4H | P09960 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983340 | 0.77 | ADRB3 (0.59) | MEN1KMT2AMAPTADRB2ADRB1 | |
| SCHEMBL6985385 | 0.72 | ADRB3 (0.47) | MEN1KMT2ALMNAMAPTADRB2 | |
| SCHEMBL6980419 | 0.72 | KMT2A (0.55) | HRH3CYP2C9MEN1KMT2AMAPT | |
| SCHEMBL5555203 | 0.72 | HRH3 (0.58) | HRH3CYP2C9MEN1KMT2ARAB9A | |
| SCHEMBL3268536 | 0.69 | KDM1A (0.68) | — | |
| SCHEMBL14313486 | 0.67 | HRH3 (0.42) | HRH3LTA4HNPC1RAB9AHPGD | |
| SCHEMBL425903 | 0.65 | LTA4H (0.63) | HRH3CYP2C9LTA4HLMNACYP1A2 | |
| SCHEMBL3212615 | 0.65 | LTA4H (0.63) | HRH3CYP2C9LTA4HLMNACYP1A2 | |
| SCHEMBL9965855 | 0.65 | ACHE (0.54) | MEN1KMT2ARAB9ABCHEACHE | |
| SCHEMBL16195402 | 0.65 | LTA4H (0.60) | HRH3LTA4HLMNACYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1328512-A2 | CYCLYLAMINE SULFONAMIDES AS BETA-3 ADRENERGIC RECEPTOR AGONISTS | Wyeth (US) | 2003-07-23 | — | — | EP | disclosed |
| WO-2002006221-A2 | CYCLYLAMINE SULFONAMIDES AS BETA-3 ADRENERGIC RECEPTOR AGONISTS | WYETH (US) | 2002-01-24 | — | — | WO | disclosed |