Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 4/20 | 0.39 |
| ▸ | CTSK | P43235 | 7/20 | 0.38 |
| ▸ | CTSL | P07711 | 7/20 | 0.36 |
| ▸ | CTSB | P07858 | 7/20 | 0.36 |
| ▸ | CTSS | P25774 | 6/20 | 0.36 |
| ▸ | CTSV | O60911 | 3/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6747834 | 0.91 | HPGDS (0.44) | HPGDSCTSKCTSLCTSBCTSS | |
| SCHEMBL6749630 | 0.91 | HPGDS (0.39) | HPGDSCTSKCTSLCTSBCTSS | |
| SCHEMBL6751642 | 0.90 | CTSL (0.45) | HPGDSCTSKCTSLCTSBCTSS | |
| SCHEMBL6752290 | 0.89 | CTSL (0.46) | HPGDSCTSLUTS2RRAB9A | |
| SCHEMBL6752292 | 0.87 | HPGDS (0.37) | HPGDSCTSLNLRP3RAB9A | |
| SCHEMBL6747703 | 0.86 | CTSL (0.40) | HPGDSCTSKCTSLCTSBCTSS | |
| SCHEMBL6749652 | 0.86 | TRPV1 (0.44) | HPGDSCTSLNLRP3 | |
| SCHEMBL6752382 | 0.86 | HPGDS (0.47) | HPGDSCTSKCTSLCTSBCTSS | |
| SCHEMBL6749624 | 0.84 | F10 (0.43) | HPGDS | |
| SCHEMBL6749632 | 0.84 | KDM1A (0.37) | HPGDSCTSLCTSBCTSSCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362042-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057249-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |