Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 16/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25332385 | 0.87 | KMT2A (0.60) | HTR1A | |
| SCHEMBL31197140 | 0.87 | KMT2A (0.60) | HTR1A | |
| SCHEMBL6987552 | 0.87 | HPGD (0.65) | HTR1AADRA1A | |
| SCHEMBL2401240 | 0.85 | HTR1A (0.51) | HTR1ADRD2DRD4DRD3 | |
| SCHEMBL4546529 | 0.85 | HPGD (0.66) | HTR1A | |
| SCHEMBL6413687 | 0.83 | HTR1A (0.48) | HTR1AADRA1ADRD2DRD4DRD3 | |
| SCHEMBL25331862 | 0.83 | PHGDH (0.61) | — | |
| Methane SCHEMBL7459255 | 0.82 | HTR1A (0.57) | HTR1AADRA1A | |
| SCHEMBL19971721 | 0.81 | HTR1A (0.58) | HTR1AADRA1A | |
| SCHEMBL2653348 | 0.81 | HPGD (0.73) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946546-B1 | PYRIDIN-2-YL-METHYLAMINE DERIVATIVES, METHOD OF PREPARING AND APPLICATION AS MEDICINE | PF MEDICAMENT (FR) | 2003-06-25 | — | — | EP | disclosed |
| US-6020345-A | Pyridin-2-yl-methylamine derivatives, method of preparing and application as medicine | PIERRE FABRE MEDICAMENT (FR) | 2000-02-01 | — | — | US | disclosed |
| EP-0946546-A1 | PYRIDIN-2-YL-METHYLAMINE DERIVATIVES, METHOD OF PREPARING AND APPLICATION AS MEDICINE | PIERRE FABRE MEDICAMENT (FR) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998022459-A1 | PYRIDIN-2-YL-METHYLAMINE DERIVATIVES, METHOD OF PREPARING AND APPLICATION AS MEDICINE | PIERRE FABRE MEDICAMENT (FR) | 1998-05-28 | — | — | WO | disclosed |