Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.41 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5841667 | 0.99 | TDP1 (0.43) | TDP1SIGMAR1SLC29A1CHRM3KCNH2 | |
| SCHEMBL5841718 | 0.85 | SLC29A1 (0.44) | SIGMAR1SLC29A1CHRM3KCNH2CHRM2 | |
| Hydrochloric Acid SCHEMBL5841791 | 0.84 | SLC29A1 (0.43) | SIGMAR1SLC29A1TLR9TLR7MEN1 | |
| SCHEMBL6985106 | 0.83 | SIGMAR1 (0.43) | SIGMAR1SLC29A1CHRM3KCNH2CHRM2 | |
| SCHEMBL6986312 | 0.83 | SIGMAR1 (0.44) | SIGMAR1CHRM3KCNH2CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL5841820 | 0.82 | SIGMAR1 (0.43) | SIGMAR1SLC29A1CHRM3KCNH2CHRM2 | |
| SCHEMBL5841208 | 0.81 | SHMT2 (0.44) | SIGMAR1SLC29A1CHRM3KCNH2CHRM2 | |
| SCHEMBL6987338 | 0.81 | KCNH2 (0.43) | SIGMAR1SLC29A1KCNH2 | |
| SCHEMBL5841662 | 0.81 | SHMT2 (0.51) | SIGMAR1MEN1CYP3A4CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL5842468 | 0.80 | KCNH2 (0.42) | SIGMAR1KCNH2MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |