SCHEMBL6985807

SCHEMBL6985807

OC[C@H]1COc2cccc(O)c2O1

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ADRA1A P35348 4/20 0.49
ADRA1D P25100 3/20 0.49
ADRA1B P35368 3/20 0.49
CA2 P00918 3/20 0.44
CHRNB4 P30926 1/20 0.39
CHRNA3 P32297 1/20 0.39
HTT P42858 1/20 0.39
HTR1A P08908 1/20 0.39
ADRA2A P08913 1/20 0.39
DRD1 P21728 1/20 0.39
TBXA2R P21731 1/20 0.39
SLC6A2 P23975 1/20 0.39
DRD3 P35462 1/20 0.39
ALDH1A1 P00352 2/20 0.38
MTNR1A P48039 1/20 0.37
ALOX15 P16050 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
TAAR1 Q96RJ0 1/20 0.37
HSD17B10 Q99714 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6985813 1.00 ADRA1A (0.49) ADRA1AADRA1DADRA1BCA2CHRNB4
SCHEMBL6981984 0.83 CA2 (0.41) ADRA1AADRA1DADRA1BCA2HTT
SCHEMBL6974656 0.83 ADRA1A (0.47) ADRA1AADRA1DADRA1BCA2HTT
SCHEMBL1021052 0.83 ADRA1A (0.47) ADRA1AADRA1DADRA1BCA2HTT
SCHEMBL6981978 0.83 CA2 (0.41) ADRA1AADRA1DADRA1BCA2HTT
SCHEMBL6982180 0.82 CA2 (0.59) ADRA1AADRA1DADRA1BCA2HTT
SCHEMBL6982176 0.82 CA2 (0.59) ADRA1AADRA1DADRA1BCA2HTT
SCHEMBL4961821 0.82 CA2 (0.40) ADRA1AADRA1DADRA1BCA2HTT
SCHEMBL4961826 0.82 CA2 (0.40) ADRA1AADRA1DADRA1BCA2HTT
SCHEMBL6977481 0.81 CA2 (0.42) ADRA1AADRA1DADRA1BCA2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0839145-B1 HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS ABBOTT GMBH & CO KG (DE) 2003-11-05 EP disclosed
US-5935973-A AFFINITY FOR 5-HT1A, ALPHA1, ALPHA2 AND/OR D2 RECEPTORS; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS, PSYCHOSES, DYSKINESIAS, PARKINSON'S DISEASE, HYPOTENSIVE AGENTS, TOURETTE'S SYNDROME, OBSESSIVE-COMPULSIVE BEHAVIOUR, PANIC ATTACKS, SOCIAL PHOBIAS KNOLL AKTIENGESELLSCHAFT (DE) 1999-08-10 US disclosed
EP-0839145-A1 HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS Knoll AG (DE) 1998-05-06 EP disclosed
WO-1997003071-A1 HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS KNOLL AKTIENGESELLSCHAFT (DE) 1997-01-30 WO disclosed