Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.57 |
| ▸ | FABP4 | P15090 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5626348 | 0.88 | KMT2A (0.58) | KMT2ASMN1; SMN2TSHRMEN1HTT | |
| SCHEMBL6985860 | 0.84 | KMT2A (0.74) | KMT2ASMN1; SMN2TSHRMEN1HTT | |
| SCHEMBL6988457 | 0.84 | KMT2A (0.74) | KMT2ASMN1; SMN2TSHRMEN1HTT | |
| SCHEMBL9872404 | 0.78 | FABP4 (0.60) | ALDH1A1TBXA2RFABP4LMNATHRB | |
| SCHEMBL1287269 | 0.76 | KMT2A (0.62) | KMT2ASMN1; SMN2TSHRMEN1HTT | |
| SCHEMBL10690110 | 0.76 | TSHR (0.89) | SMN1; SMN2TSHRMAPK1ALDH1A1TBXA2R | |
| SCHEMBL9871736 | 0.75 | TBXA2R (0.75) | ALDH1A1TBXA2RFABP4LMNA | |
| SCHEMBL9869922 | 0.75 | TBXA2R (0.75) | ALDH1A1TBXA2RFABP4LMNA | |
| SCHEMBL9870233 | 0.75 | TBXA2R (0.75) | ALDH1A1TBXA2RFABP4LMNA | |
| SCHEMBL9872413 | 0.75 | TBXA2R (0.75) | ALDH1A1TBXA2RFABP4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1989001330-A2 | W-ARYLSULPHONAMIDOALKANOIC ACIDS FOR TREATMENT OF THROMBOXANE MEDIATED DISEASES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-02-23 | — | — | WO | claimed |
| EP-0304271-A2 | Omega-arylsulphonamidoalkanoic acids for treatment of thromboxane medited diseases | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-02-22 | — | — | EP | claimed |
| US-4997847-A | Thromboxane A2 antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (DE) | 1991-03-05 | — | — | US | disclosed |
| EP-0304271-A2 | Omega-arylsulphonamidoalkanoic acids for treatment of thromboxane medited diseases | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-02-22 | — | — | EP | disclosed |