Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMOX2 | P30519 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980337 | 0.91 | ADAM17 (0.33) | ADAM17 | |
| SCHEMBL6986290 | 0.85 | CYP19A1 (0.34) | TBXAS1MMP2HRH4 | |
| SCHEMBL6986412 | 0.85 | ADAM17 (0.39) | ADAM17MMP2MMP9MMP8 | |
| SCHEMBL6937767 | 0.85 | ADAM17 (0.39) | ADAM17MMP2MMP9MMP8 | |
| Hydrochloric Acid SCHEMBL6983390 | 0.83 | ADAM17 (0.38) | ADAM17MMP2MMP9MMP8 | |
| SCHEMBL6945158 | 0.83 | ADAM17 (0.41) | ADAM17MMP2MMP9MMP8 | |
| SCHEMBL7813141 | 0.82 | ADAM17 (0.39) | ADAM17MMP2MMP9MMP8 | |
| Hydrochloric Acid SCHEMBL6978179 | 0.82 | ADAM17 (0.38) | ADAM17MMP2MMP9MMP8 | |
| SCHEMBL6983160 | 0.82 | ADAM17 (0.38) | ADAM17MMP2MMP9MMP8 | |
| SCHEMBL6982488 | 0.82 | ADAM17 (0.38) | ADAM17MMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | claimed |
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |