SCHEMBL6985972

SCHEMBL6985972

CC1Cc2ccccc2C1(C)O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.42
MEN1 O00255 1/20 0.42
CYP2D6 P10635 1/20 0.42
ALOX15 P16050 1/20 0.42
CYP2C19 P33261 1/20 0.42
KMT2A Q03164 1/20 0.42
GRIN2D O15399 1/20 0.42
GRIN3B O60391 1/20 0.42
BCHE P06276 1/20 0.42
CHRM5 P08912 1/20 0.42
TSHR P16473 1/20 0.42
ALOX12 P18054 1/20 0.42
NFKB1 P19838 1/20 0.42
MAPK1 P28482 1/20 0.42
PRCP P42785 1/20 0.42
GRIN1 Q05586 1/20 0.42
GRIN2A Q12879 1/20 0.42
GRIN2B Q13224 1/20 0.42
GRIN2C Q14957 1/20 0.42
GRIN3A Q8TCU5 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6838308 0.81 CYP3A4 (0.40) CYP3A4MEN1CYP2D6ALOX15CYP2C19
SCHEMBL414650 0.79 CYP3A4 (0.44) CYP3A4MEN1CYP2D6ALOX15CYP2C19
SCHEMBL28280087 0.78 CYP3A4 (0.38) CYP3A4MEN1CYP2D6ALOX15CYP2C19
SCHEMBL26125997 0.78 CYP3A4 (0.41) CYP3A4MEN1CYP2D6ALOX15CYP2C19
SCHEMBL28302686 0.78 CYP3A4 (0.41) CYP3A4MEN1CYP2D6ALOX15CYP2C19
Benzene SCHEMBL28485309 0.78 SIGMAR1 (0.44) CYP3A4MEN1CYP2D6ALOX15CYP2C19
Hydrochloric Acid SCHEMBL28152573 0.78 CYP3A4 (0.43) CYP3A4MEN1CYP2D6ALOX15CYP2C19
SCHEMBL2466865 0.76 KDM1A (0.43) CYP3A4MEN1CYP2D6ALOX15CYP2C19
SCHEMBL10595033 0.76 CYP3A4 (0.42) CYP3A4MEN1CYP2D6ALOX15CYP2C19
SCHEMBL3455254 0.76 CYP3A4 (0.42) CYP3A4MEN1CYP2D6ALOX15CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1276739-A2 HETEROCYCLES THAT ARE INHIBITORS OF IMPDH ENZYME Bristol-Myers Squibb Company (US) 2003-01-22 EP disclosed
WO-2001081340-A2 HETEROCYCLES THAT ARE INHIBITORS OF IMPDH ENZYME BRISTOL-MYERS SQUIBB COMPANY (US) 2001-11-01 WO disclosed
US-4510337-A REACTION OF PHENOLS WITH ISOPRENE OR 2,3-DIMETHYL-1,3-BUTADIENE IN THE PRESENCE OF PHOSPHORIC ACID PHILLIPS PETROLEUM COMPANY (US) 1985-04-09 US disclosed