SCHEMBL2466865

SCHEMBL2466865

CC1Cc2ccccc2C1(C)N

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 1/20 0.43
CYP3A4 P08684 2/20 0.42
MEN1 O00255 1/20 0.42
CYP2D6 P10635 1/20 0.42
ALOX15 P16050 1/20 0.42
CYP2C19 P33261 1/20 0.42
KMT2A Q03164 1/20 0.42
GRIN2D O15399 1/20 0.42
GRIN3B O60391 1/20 0.42
BCHE P06276 1/20 0.42
CHRM5 P08912 1/20 0.42
TSHR P16473 1/20 0.42
ALOX12 P18054 1/20 0.42
NFKB1 P19838 1/20 0.42
MAPK1 P28482 1/20 0.42
PRCP P42785 1/20 0.42
GRIN1 Q05586 1/20 0.42
GRIN2A Q12879 1/20 0.42
GRIN2B Q13224 1/20 0.42
GRIN2C Q14957 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL28943323 0.90 LMNA (0.41) KDM1ACYP3A4MEN1CYP2D6ALOX15
Fumaric Acid SCHEMBL28943372 0.86 LMNA (0.53)
SCHEMBL9054248 0.81 KDM1A (0.45) KDM1ACYP3A4MEN1CYP2D6ALOX15
SCHEMBL9053824 0.81 KDM1A (0.41) KDM1ACYP3A4MEN1CYP2D6ALOX15
SCHEMBL414650 0.79 CYP3A4 (0.44) CYP3A4MEN1CYP2D6ALOX15CYP2C19
Benzene SCHEMBL28485309 0.78 SIGMAR1 (0.44) CYP3A4MEN1CYP2D6ALOX15CYP2C19
Hydrochloric Acid SCHEMBL28152573 0.78 CYP3A4 (0.43) CYP3A4MEN1CYP2D6ALOX15CYP2C19
SCHEMBL3455254 0.76 CYP3A4 (0.42) CYP3A4MEN1CYP2D6ALOX15CYP2C19
SCHEMBL10595033 0.76 CYP3A4 (0.42) CYP3A4MEN1CYP2D6ALOX15CYP2C19
SCHEMBL6985972 0.76 CYP3A4 (0.42) CYP3A4MEN1CYP2D6ALOX15CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4782252-B2 2011-09-28 JP claimed
EP-0738149-A4 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF TEVA PHARMA (IL) 1999-10-27 EP claimed
EP-0738149-A1 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) 1996-10-23 EP claimed
WO-1995018617-A1 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 1995-07-13 WO claimed
CN-108794339-B Preparation method of (1R, 2S) -2, 6-dimethyl-1-aminoindane 上海朴颐化学科技有限公司 2023-01-20 CN disclosed
EP-3475273-A1 3-AMINO-1,2,4-TRIAZINE DERIVATIVES AND THEIR USE FOR CONTROLLING UNDESIRED PLANT GROWTH Bayer CropScience Aktiengesellschaft (DE) 2019-05-01 EP disclosed
CN-107074824-A Phthalazine derivatives of formula (I) as PCAF and GCN5 inhibitors for the treatment of cancer 基因泰克公司 2017-08-18 CN disclosed
CN-106795115-A Difluoromethyl nicotine indanyl formamide 拜耳作物科学股份公司 2017-05-31 CN disclosed
EP-0738149-A4 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF TEVA PHARMA (IL) 1999-10-27 EP disclosed
EP-0738149-A1 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) 1996-10-23 EP disclosed
WO-1996021640-A1 OPTICALLY ACTIVE AMINOINDANE DERIVATIVES AND PREPARATION THEREOF TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) 1996-07-18 WO disclosed
WO-1995018617-A1 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 1995-07-13 WO disclosed