Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985924 | 0.84 | CNR2 (0.45) | KDM4EHSD17B10CNR2ALDH1A1SIRT2 | |
| SCHEMBL6983099 | 0.79 | F2 (0.47) | KDM4EHSD17B10HPGDPTGER4 | |
| SCHEMBL11442111 | 0.75 | KDM4E (0.71) | KDM4EHTTRAD52TDP1ALDH1A1 | |
| SCHEMBL11443284 | 0.73 | KDM4E (0.74) | KDM4EHTTHSD17B10RAD52TDP1 | |
| SCHEMBL11440211 | 0.70 | KDM4E (0.73) | KDM4EHTTHSD17B10RAD52TDP1 | |
| SCHEMBL27188330 | 0.67 | KDM4E (0.57) | KDM4EHTTHSD17B10RAD52TDP1 | |
| SCHEMBL20810772 | 0.67 | MYC (0.44) | KDM4EHTTHSD17B10RAD52PTGER4 | |
| SCHEMBL17199042 | 0.66 | KDM4E (0.62) | KDM4EHTTRAD52TDP1ALDH1A1 | |
| SCHEMBL2882835 | 0.65 | KDM4E (0.62) | KDM4EHTTRAD52ALDH1A1HPGD | |
| SCHEMBL20982514 | 0.64 | KDM4E (0.68) | KDM4EHTTHSD17B10RAD52TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1220844-B1 | ARYL SULFONAMIDE-SUBSTITUTED BENZIMIDAZOL DERIVATIVES THEREOF AS TRYPTASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-04-09 | — | — | EP | disclosed |
| EP-1220844-A1 | ARYL SULFONAMIDE-SUBSTITUTED BENZIMIDAZOL DERIVATIVES THEREOF AS TRYPTASE INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-07-10 | — | — | EP | disclosed |
| US-6365584-B1 | FOR PROPHYLAXIS AND THERAPY OF INFLAMMATORY AND/OR ALLERGIC DISEASES, LUNG FIBROSIS, FIBROSING ALVEOLITIS AND SCARRING, COLLAGENOSES SUCH AS LUPUS ERYTHEMATODES AND SCLERODERMIA AS WELL AS ARTERIOSCLEROSIS, PSORIASIS AND NEOPLASM | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-04-02 | — | — | US | disclosed |
| WO-2001023360-A1 | ARYL SULFONAMIDE-SUBSTITUTED BENZIMIDAZOL DERIVATIVES THEREOF AS TRYPTASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-04-05 | — | — | WO | disclosed |