Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | RAD52 | P43351 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 12/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11440211 | 0.90 | KDM4E (0.73) | KDM4ERAD52ALDH1A1HPGDHTT | |
| SCHEMBL10252674 | 0.85 | NLRP3 (0.76) | KDM4ERAD52ALDH1A1HPGDHTT | |
| SCHEMBL17199042 | 0.84 | KDM4E (0.62) | KDM4ERAD52ALDH1A1HPGDHTT | |
| SCHEMBL1378639 | 0.84 | CYP11B2 (0.62) | KDM4ERAD52ALDH1A1HPGDHTT | |
| SCHEMBL175221 | 0.80 | NLRP3 (0.52) | KDM4EALDH1A1HPGDHTTNLRP3 | |
| SCHEMBL616998 | 0.79 | KDM4E (0.97) | KDM4ERAD52ALDH1A1HPGDHTT | |
| SCHEMBL11443284 | 0.78 | KDM4E (0.74) | KDM4ERAD52ALDH1A1HPGDHTT | |
| Hydrochloric Acid SCHEMBL16736724 | 0.77 | KDM4E (1.00) | KDM4ERAD52ALDH1A1HPGDHTT | |
| Hydrochloric Acid SCHEMBL6605580 | 0.77 | KDM4E (1.00) | KDM4ERAD52ALDH1A1HPGDHTT | |
| SCHEMBL10252666 | 0.77 | NLRP3 (0.58) | KDM4EALDH1A1HPGDHTTNLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946227-B2 | Piperazine derivatives and methods of use | MERCK SERONO SA (CH) | 2015-02-03 | — | — | US | claimed |
| US-20130143893-A1 | PIPERAZINE DERIVATIVES AND METHODS OF USE | MERCK SERONO SA (CH) | 2013-06-06 | — | — | US | claimed |
| EP-1542993-B1 | PIPERAZINE DERIVATIVES AND METHODS OF USE | MERCK SERONO SA (CH) | 2012-12-19 | — | — | EP | claimed |
| US-20100305137-A1 | PIPERAZINE DERIVATIVES AND METHODS OF USE | MERCK SERONO SA (CH) | 2010-12-02 | — | — | US | claimed |
| US-7754722-B2 | Piperazine derivatives and methods of use | MERCK SERONO SA (CH) | 2010-07-13 | — | — | US | claimed |
| US-20060223813-A1 | Piperazine Derivatives and Methods of Use | MERCK SERONO SA (CH) | 2006-10-05 | — | — | US | claimed |
| EP-1542993-A1 | PIPERAZINE DERIVATIVES AND METHODS OF USE | Applied Research Systems ARS Holding N.V. (AN) | 2005-06-22 | — | — | EP | claimed |
| WO-2004031182-A1 | PIPERAZINE DERIVATIVES AND METHODS OF USE | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-04-15 | — | — | WO | claimed |
| US-8946227-B2 | Piperazine derivatives and methods of use | MERCK SERONO SA (CH) | 2015-02-03 | — | — | US | disclosed |
| US-20130143893-A1 | PIPERAZINE DERIVATIVES AND METHODS OF USE | MERCK SERONO SA (CH) | 2013-06-06 | — | — | US | disclosed |
| EP-1542993-B1 | PIPERAZINE DERIVATIVES AND METHODS OF USE | MERCK SERONO SA (CH) | 2012-12-19 | — | — | EP | disclosed |
| US-20100305137-A1 | PIPERAZINE DERIVATIVES AND METHODS OF USE | MERCK SERONO SA (CH) | 2010-12-02 | — | — | US | disclosed |
| US-7754722-B2 | Piperazine derivatives and methods of use | MERCK SERONO SA (CH) | 2010-07-13 | — | — | US | disclosed |
| US-20060223813-A1 | Piperazine Derivatives and Methods of Use | MERCK SERONO SA (CH) | 2006-10-05 | — | — | US | disclosed |
| EP-1542993-A1 | PIPERAZINE DERIVATIVES AND METHODS OF USE | Applied Research Systems ARS Holding N.V. (AN) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004031182-A1 | PIPERAZINE DERIVATIVES AND METHODS OF USE | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305137-A1 | PIPERAZINE DERIVATIVES AND METHODS OF USE | CATSPER1, NASP, HDAC5 | KDM4E 515/4885RAD52 3556/4885ALDH1A1 568/4885 |
| US-20130143893-A1 | PIPERAZINE DERIVATIVES AND METHODS OF USE | CATSPER1, NASP, HDAC5 | KDM4E 515/4885RAD52 3556/4885ALDH1A1 568/4885 |
| US-20060223813-A1 | Piperazine Derivatives and Methods of Use | CATSPER1, H1-5, GNRHR | KDM4E 1207/4885RAD52 2706/4885ALDH1A1 1182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.