Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10339406 | 0.79 | — | — | |
| SCHEMBL351018 | 0.75 | KDM5B (0.37) | CYP1A2TSHR | |
| SCHEMBL7702290 | 0.73 | TDP1 (0.30) | — | |
| SCHEMBL7752566 | 0.71 | EPHX1 (0.37) | CYP1A2LMNAKDM4E | |
| SCHEMBL348208 | 0.69 | TSHR (0.40) | TSHRTHPOLMNA | |
| SCHEMBL301095 | 0.69 | — | — | |
| SCHEMBL168766 | 0.69 | — | — | |
| SCHEMBL7377614 | 0.69 | L3MBTL1 (0.42) | CYP1A2TSHRNFKB1MAOAMAOB | |
| SCHEMBL10402594 | 0.69 | EPHX1 (0.41) | NFKB1KDM4E | |
| SCHEMBL13245283 | 0.69 | TSHR (0.39) | TSHRNFKB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1048667-B1 | Process for preparing 8-cyclopentyl-6-ethyl-3-(substituted)-5,8-dihydro-4H-1,2,3A,7,8-pentaaza-as-indacenes and intermediates useful therein | PFIZER PROD INC (US) | 2003-10-22 | — | — | EP | claimed |