Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45780 | 0.84 | KDM4E (0.68) | KDM4EMAPTPLAUACHEALDH1A1 | |
| SCHEMBL6983698 | 0.77 | KDM4E (0.62) | KDM4EMAPTPLAUACHEALDH1A1 | |
| SCHEMBL29673258 | 0.77 | KDM4E (1.00) | KDM4EMAPTPLAUACHEALDH1A1 | |
| SCHEMBL45202 | 0.77 | KDM4E (1.00) | KDM4EMAPTPLAUACHEALDH1A1 | |
| SCHEMBL3096482 | 0.76 | MAPT (0.73) | KDM4EMAPTPLAUACHEALDH1A1 | |
| SCHEMBL21499389 | 0.75 | NR1H4 (0.52) | KDM4EMAPTPLAUACHEALDH1A1 | |
| SCHEMBL8511891 | 0.75 | KDM4E (0.54) | KDM4EMAPTACHEALDH1A1ALOX15 | |
| SCHEMBL30011603 | 0.73 | KDM4E (0.73) | KDM4EMAPTPLAUACHEALDH1A1 | |
| SCHEMBL28039955 | 0.73 | MAPT (0.73) | KDM4EMAPTPLAUACHEALDH1A1 | |
| SCHEMBL12486871 | 0.73 | KDM4E (0.73) | KDM4EMAPTPLAUACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991624-B1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-11-19 | — | — | EP | disclosed |
| US-6300342-B1 | FOR THERAPY OR INHIBITING THROMBUS FORMATION; FOR THERAPY OF FIBRIN-DEPENDENT INFLAMMATORY CONDITION | BOEHRINGER INGELHEIM PHARM KG (DE) | 2001-10-09 | — | — | US | disclosed |