Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | KIF11 | P52732 | 2/20 | 0.32 |
| ▸ | CASR | P41180 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14390738 | 0.77 | TSHR (0.40) | TSHRESR1ESR2ARKIF11 | |
| SCHEMBL19237292 | 0.77 | TSHR (0.40) | TSHRESR1ESR2ARKIF11 | |
| SCHEMBL604108 | 0.77 | TSHR (0.50) | TSHRARKIF11CASRMAPT | |
| SCHEMBL13946948 | 0.75 | TSHR (0.41) | TSHRKIF11CASRSSTR4SLC6A2 | |
| SCHEMBL28778794 | 0.74 | TSHR (0.40) | TSHRKIF11CASRSSTR4SLC6A2 | |
| SCHEMBL5779039 | 0.74 | ALDH1A1 (0.46) | TSHRESR1ESR2MAPT | |
| SCHEMBL6990801 | 0.73 | TSHR (0.39) | TSHRKIF11CASRSLC6A2SLC6A4 | |
| SCHEMBL5879396 | 0.73 | SIGMAR1 (0.36) | TSHRKIF11 | |
| SCHEMBL13946950 | 0.72 | TSHR (0.38) | TSHRKIF11CASRSSTR4SLC6A2 | |
| SCHEMBL4026261 | 0.72 | TSHR (0.41) | TSHRKIF11SSTR4SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370520-A1 | ARYL AND BIARYL COMPOUNDS HAVING MCH MODULATORY ACTIVITY | PHARMACOPEIA, INC. (US) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002076929-A1 | ARYL AND BIARYL COMPOUNDS HAVING MCH MODULATORY ACTIVITY | PHARMACOPEIA, INC. (US) | 2002-10-03 | — | — | WO | disclosed |