Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL6986318 | 1.00 | ACHE (0.84) | ACHEBCHE | |
| Fumaric Acid SCHEMBL6986325 | 1.00 | ACHE (0.84) | ACHEBCHE | |
| Maleic Acid SCHEMBL27339109 | 1.00 | ACHE (0.84) | ACHEBCHE | |
| Fumaric Acid SCHEMBL6989971 | 0.94 | ACHE (0.84) | ACHEBCHE | |
| Maleic Acid SCHEMBL6989962 | 0.94 | ACHE (0.84) | ACHEBCHE | |
| Benzenesulfonamide SCHEMBL6987516 | 0.93 | ACHE (0.72) | ACHEBCHE | |
| Benzenesulfonamide SCHEMBL6988132 | 0.93 | ACHE (0.72) | ACHEBCHE | |
| SCHEMBL6985471 | 0.92 | ACHE (1.00) | ACHEBCHE | |
| Maleic Acid SCHEMBL27352167 | 0.91 | ACHE (0.69) | ACHEBCHE | |
| Maleic Acid SCHEMBL27352164 | 0.91 | ACHE (0.69) | ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0646115-B1 | HETEROCYCLIC-CYCLIC AMINE DERIVATIVES | EISAI CO LTD (JP) | 2003-01-22 | — | — | EP | disclosed |
| US-5538984-A | Methods of using piperidyl-benzisoxazole and benisothiazole derivatives as cholinesterase inhibitors | PFIZER INC. (US) | 1996-07-23 | — | — | US | disclosed |