Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | HTR7 | P34969 | 3/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6986394 | 0.81 | KDM4E (0.54) | HDAC3HDAC1HDAC8NCOR2HSD17B10 | |
| SCHEMBL30072993 | 0.76 | ALDH1A1 (0.59) | KDM4EALDH1A1SIGMAR1DRD3HTR1A | |
| SCHEMBL16993484 | 0.74 | HDAC3 (0.55) | HDAC3HDAC1HDAC8NCOR2HSD17B10 | |
| SCHEMBL377727 | 0.73 | ALDH1A1 (0.52) | HDAC3HDAC1HDAC8NCOR2HSD17B10 | |
| SCHEMBL6712670 | 0.73 | ALDH1A1 (0.52) | HSD17B10KDM4EALDH1A1TMEM97SIGMAR1 | |
| SCHEMBL377728 | 0.73 | ALDH1A1 (0.52) | HDAC3HDAC1HDAC8NCOR2HSD17B10 | |
| SCHEMBL29367146 | 0.73 | ALDH1A1 (0.52) | HDAC3HDAC1HDAC8NCOR2HSD17B10 | |
| SCHEMBL30969293 | 0.72 | ALDH1A1 (0.51) | HDAC3HDAC1HDAC8NCOR2HSD17B10 | |
| SCHEMBL3477555 | 0.72 | HDAC3 (0.70) | HDAC3HDAC1HDAC8NCOR2KDM4E | |
| Hydrochloric Acid SCHEMBL25366946 | 0.71 | ALDH1A1 (0.50) | HDAC3HDAC1HDAC8NCOR2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |