Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 5/20 | 0.49 |
| ▸ | NOS3 | P29474 | 3/20 | 0.47 |
| ▸ | NOS2 | P35228 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4404172 | 0.89 | NOS1 (0.46) | NOS1NOS3NOS2HPGDMEN1 | |
| SCHEMBL6969041 | 0.79 | NOS3 (0.67) | NOS1NOS3NOS2HPGDMEN1 | |
| SCHEMBL4399592 | 0.78 | NOS1 (0.50) | NOS1NOS3NOS2HPGDALDH1A1 | |
| SCHEMBL4399594 | 0.78 | NOS1 (0.50) | NOS1NOS3NOS2HPGDALDH1A1 | |
| SCHEMBL6958481 | 0.77 | NOS1 (0.62) | NOS1NOS3NOS2 | |
| SCHEMBL6986527 | 0.77 | NOS1 (0.47) | NOS1NOS3NOS2HPGDMEN1 | |
| SCHEMBL6986511 | 0.77 | NOS1 (0.47) | NOS1NOS3NOS2HPGDMEN1 | |
| SCHEMBL4396229 | 0.76 | NOS1 (0.66) | NOS1NOS3MEN1KMT2A | |
| SCHEMBL4400410 | 0.75 | NOS1 (0.49) | NOS1NOS3NOS2HPGDALDH1A1 | |
| SCHEMBL4400407 | 0.75 | NOS1 (0.49) | NOS1NOS3NOS2HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115719-A2 | NOVEL AMIDINE DERIVATIVES, THEIR PREPARATION AND APPLICATION AS MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2001-07-18 | — | — | EP | claimed |
| WO-2000017190-A2 | AMIDINE DERIVATIVES, THEIR PREPARATION AND APPLICATION AS MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2000-03-30 | — | — | WO | claimed |
| US-6653312-B1 | Such as 3-((3-((amino(2-thienyl)methylideneamino)-benzyl)-amino)-N-(1- methyl-2,3-dihydro-1H-indol-5-yl)propanamide; NO-synthase enzyme inhibitors | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2003-11-25 | — | — | US | disclosed |
| EP-1318149-A1 | Amidine derivatives, their preparation and application as medicines and pharmaceutical compositions containing them | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) | 2003-06-11 | — | — | EP | disclosed |
| EP-1115719-A2 | NOVEL AMIDINE DERIVATIVES, THEIR PREPARATION AND APPLICATION AS MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017190-A2 | AMIDINE DERIVATIVES, THEIR PREPARATION AND APPLICATION AS MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2000-03-30 | — | — | WO | disclosed |