Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.47 |
| ▸ | CTSC | P53634 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13133357 | 0.83 | SIGMAR1 (0.44) | SIGMAR1CTSCPOLBCYP3A4TSHR | |
| SCHEMBL9768698 | 0.73 | SIGMAR1 (0.58) | SIGMAR1ATMTAAR1OPRK1POLB | |
| SCHEMBL19334491 | 0.73 | SIGMAR1 (0.58) | SIGMAR1ATMTAAR1OPRK1POLB | |
| SCHEMBL18435350 | 0.72 | SIGMAR1 (0.72) | SIGMAR1ATMTAAR1OPRK1SMN1; SMN2 | |
| SCHEMBL10939197 | 0.70 | SIGMAR1 (0.55) | SIGMAR1ATMTAAR1OPRK1POLB | |
| SCHEMBL7284929 | 0.70 | SIGMAR1 (0.55) | SIGMAR1ATMTAAR1OPRK1POLB | |
| SCHEMBL24019759 | 0.69 | SIGMAR1 (0.47) | SIGMAR1CTSCPOLBCYP1A2CYP3A4 | |
| SCHEMBL9150896 | 0.69 | SIGMAR1 (0.62) | SIGMAR1ATMTAAR1 | |
| SCHEMBL1148376 | 0.69 | SIGMAR1 (0.68) | SIGMAR1ATMTAAR1OPRK1NPC1 | |
| SCHEMBL1168748 | 0.69 | SIGMAR1 (0.45) | SIGMAR1POLBALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341779-A2 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | Wyeth (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002057252-A2 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH (US) | 2002-07-25 | — | — | WO | disclosed |