Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 18/20 | 0.75 |
| ▸ | AVPR1B | P47901 | 15/20 | 0.75 |
| ▸ | AVPR2 | P30518 | 12/20 | 0.75 |
| ▸ | OXTR | P30559 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8742945 | 0.86 | AVPR1A (1.00) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL9054176 | 0.84 | AVPR1A (0.64) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL7371679 | 0.84 | AVPR1A (0.53) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL7339550 | 0.82 | AVPR1A (0.51) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL6989377 | 0.81 | AVPR1A (0.55) | AVPR1AAVPR1BAVPR2 | |
| SCHEMBL7335534 | 0.80 | AVPR2 (0.57) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL6988392 | 0.79 | AVPR1A (0.64) | AVPR1AAVPR1BAVPR2 | |
| SCHEMBL7335695 | 0.79 | AVPR2 (0.58) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL8741346 | 0.78 | AVPR1A (0.81) | AVPR1AAVPR1BAVPR2 | |
| SCHEMBL26406260 | 0.77 | AVPR1A (0.51) | AVPR1AAVPR1BAVPR2OXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811008-B1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2003-10-01 | — | — | EP | claimed |
| US-5696112-A | TREATMENT OF CONGESTIVE HEART FAILURE, CORONARY VASOCONSTRICTION | AMERICAN CYANAMID COMPANY (US) | 1997-12-09 | — | — | US | claimed |
| US-5654297-A | CONGESTIVE HEART FAILURE, CARDIOVASCULAR DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1997-08-05 | — | — | US | claimed |
| WO-1996022294-A1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | claimed |