Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 13/20 | 0.55 |
| ▸ | AVPR1B | P47901 | 11/20 | 0.55 |
| ▸ | AVPR2 | P30518 | 9/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9054176 | 0.85 | AVPR1A (0.64) | AVPR1AAVPR1BAVPR2 | |
| SCHEMBL6988392 | 0.83 | AVPR1A (0.64) | AVPR1AAVPR1BAVPR2 | |
| SCHEMBL6986830 | 0.81 | AVPR1A (0.75) | AVPR1AAVPR1BAVPR2 | |
| SCHEMBL6993483 | 0.77 | AVPR1A (0.56) | AVPR1AAVPR1BAVPR2ALDH1A1 | |
| SCHEMBL8801105 | 0.76 | AVPR2 (0.72) | AVPR1AAVPR1BAVPR2NPC1RAB9A | |
| SCHEMBL5237534 | 0.73 | SMN1; SMN2 (0.58) | NPC1RAB9ASMN1; SMN2PKMALDH1A1 | |
| SCHEMBL6993554 | 0.72 | AVPR1A (0.67) | AVPR1AAVPR1BAVPR2NPC1RAB9A | |
| SCHEMBL5233576 | 0.72 | SMN1; SMN2 (0.56) | NPC1RAB9ASMN1; SMN2PKMALDH1A1 | |
| SCHEMBL6989046 | 0.71 | AVPR1A (1.00) | AVPR1AAVPR1BAVPR2 | |
| SCHEMBL7342147 | 0.71 | SMN1; SMN2 (0.46) | AVPR1AAVPR2RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811008-B1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2003-10-01 | — | — | EP | disclosed |
| US-5696112-A | TREATMENT OF CONGESTIVE HEART FAILURE, CORONARY VASOCONSTRICTION | AMERICAN CYANAMID COMPANY (US) | 1997-12-09 | — | — | US | disclosed |
| US-5654297-A | CONGESTIVE HEART FAILURE, CARDIOVASCULAR DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| WO-1996022294-A1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |