Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 13/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 13/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990481 | 0.89 | CYP11B1 (0.48) | CYP11B1CYP11B2L3MBTL1KMT2A | |
| Pyroquilon SCHEMBL29473298 | 0.78 | MAP2K1 (0.53) | CYP11B1CYP11B2L3MBTL1CYP19A1 | |
| Pyroquilon SCHEMBL29473299 | 0.78 | MAP2K1 (0.53) | CYP11B1CYP11B2L3MBTL1CYP19A1 | |
| Pyroquilon SCHEMBL8820252 | 0.78 | MAP2K1 (0.55) | CYP11B1CYP11B2L3MBTL1CYP19A1 | |
| Pyroquilon SCHEMBL29473240 | 0.78 | MAP2K1 (0.55) | CYP11B1CYP11B2L3MBTL1CYP19A1 | |
| Pyroquilon SCHEMBL22234 | 0.78 | MAP2K1 (0.55) | CYP11B1CYP11B2L3MBTL1CYP19A1 | |
| Pyroquilon SCHEMBL29473172 | 0.76 | MAP2K1 (0.54) | CYP11B1CYP11B2L3MBTL1CYP19A1 | |
| Pyroquilon SCHEMBL19409911 | 0.76 | MAP2K1 (0.54) | CYP11B1CYP11B2L3MBTL1CYP19A1 | |
| SCHEMBL6992548 | 0.76 | NPC1 (0.50) | KMT2ATDP1 | |
| SCHEMBL7134349 | 0.74 | CYP11B1 (0.66) | CYP11B1CYP11B2L3MBTL1CYP19A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0607864-B1 | Tricyclic condensed heterocyclic compounds for the treatment of senile dementic | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-09-17 | — | — | EP | claimed |
| US-5527800-A | A 4H-PYRROLO(3,2,1-IJ)QUINOLIN-8-YL DERIVATIVE ADMINISTERED FOR THERAPY OR PROPHYLAXIS OF SENILE DEMENTIA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-06-18 | — | — | US | claimed |
| EP-0607864-A2 | Tricyclic condensed heterocyclic compounds for the treatment of senile dementic | Takeda Chemical Industries, Ltd. (JP) | 1994-07-27 | — | — | EP | claimed |
| EP-0607864-B1 | Tricyclic condensed heterocyclic compounds for the treatment of senile dementic | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-09-17 | — | — | EP | disclosed |