Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986853 | 0.89 | CYP11B1 (0.50) | CYP11B1CYP11B2KMT2AL3MBTL1 | |
| SCHEMBL6992548 | 0.87 | NPC1 (0.50) | KMT2A | |
| SCHEMBL6989332 | 0.82 | NPC1 (0.46) | KMT2A | |
| SCHEMBL1762224 | 0.79 | CES1 (0.57) | CYP11B1CYP11B2 | |
| SCHEMBL1762467 | 0.76 | CYP11B1 (0.54) | CYP11B1CYP11B2KMT2A | |
| SCHEMBL14305454 | 0.76 | CYP11B1 (0.54) | CYP11B1CYP11B2KMT2A | |
| SCHEMBL224329 | 0.71 | KMT2A (0.47) | KMT2AL3MBTL1 | |
| SCHEMBL6748112 | 0.70 | NPC1 (0.51) | CYP11B1CYP11B2KMT2A | |
| SCHEMBL31260123 | 0.70 | CYP11B1 (0.47) | CYP11B1CYP11B2KMT2A | |
| SCHEMBL15850375 | 0.70 | CYP11B1 (0.47) | CYP11B1CYP11B2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0607864-B1 | Tricyclic condensed heterocyclic compounds for the treatment of senile dementic | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-09-17 | — | — | EP | claimed |
| EP-0607864-A2 | Tricyclic condensed heterocyclic compounds for the treatment of senile dementic | Takeda Chemical Industries, Ltd. (JP) | 1994-07-27 | — | — | EP | claimed |
| EP-0607864-B1 | Tricyclic condensed heterocyclic compounds for the treatment of senile dementic | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-09-17 | — | — | EP | disclosed |