Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989332 | 0.95 | NPC1 (0.46) | NPC1TTRMAPTKMT2ALMNA | |
| SCHEMBL6990481 | 0.87 | CYP11B1 (0.48) | KMT2A | |
| SCHEMBL988203 | 0.76 | CES1 (0.56) | NPC1TTRMAPTKMT2ALMNA | |
| SCHEMBL6986853 | 0.76 | CYP11B1 (0.50) | KMT2ATDP1 | |
| SCHEMBL29876793 | 0.75 | NPC1 (0.57) | NPC1TTRMAPTKMT2ALMNA | |
| SCHEMBL11717588 | 0.75 | NPC1 (0.57) | NPC1TTRMAPTKMT2ALMNA | |
| SCHEMBL11714046 | 0.75 | NPC1 (0.57) | NPC1TTRMAPTKMT2ALMNA | |
| SCHEMBL11714271 | 0.75 | NPC1 (0.61) | NPC1TTRMAPTKMT2ALMNA | |
| SCHEMBL9560034 | 0.71 | CES1 (0.50) | NPC1TTRMAPTKMT2ALMNA | |
| SCHEMBL29876747 | 0.70 | NPC1 (0.68) | NPC1TTRMAPTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0607864-B1 | Tricyclic condensed heterocyclic compounds for the treatment of senile dementic | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-09-17 | — | — | EP | claimed |
| US-5527800-A | A 4H-PYRROLO(3,2,1-IJ)QUINOLIN-8-YL DERIVATIVE ADMINISTERED FOR THERAPY OR PROPHYLAXIS OF SENILE DEMENTIA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-06-18 | — | — | US | claimed |
| EP-0607864-A2 | Tricyclic condensed heterocyclic compounds for the treatment of senile dementic | Takeda Chemical Industries, Ltd. (JP) | 1994-07-27 | — | — | EP | claimed |
| EP-0607864-B1 | Tricyclic condensed heterocyclic compounds for the treatment of senile dementic | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-09-17 | — | — | EP | disclosed |