Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 4/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983831 | 1.00 | CTSK (0.44) | CTSKCA5ACTSLCTSSCAPN1 | |
| SCHEMBL6981067 | 0.92 | CTSK (0.46) | CTSKCA5ACTSLCTSSCAPN1 | |
| SCHEMBL6986438 | 0.89 | CTSK (0.45) | CTSKCA5ACTSLCTSSCTSB | |
| SCHEMBL6986262 | 0.85 | CTSK (0.44) | CTSKCTSLCTSSCAPN1CTSB | |
| SCHEMBL6985021 | 0.82 | CTSK (0.45) | CTSKCTSLCTSSCAPN1CTSB | |
| SCHEMBL6982376 | 0.81 | CTSK (0.41) | CTSKCTSLCTSSCTSB | |
| SCHEMBL6982649 | 0.77 | ANPEP (0.40) | — | |
| SCHEMBL7805789 | 0.72 | CTSK (0.44) | CTSKCTSLCTSSCTSB | |
| SCHEMBL6940820 | 0.72 | ECE1 (0.38) | CTSKCA5ACTSLCTSSCTSB | |
| SCHEMBL28546805 | 0.71 | CTSK (0.62) | CTSKCTSLCTSSCTSBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |