Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 5/20 | 0.40 |
| ▸ | MMP2 | P08253 | 3/20 | 0.40 |
| ▸ | MMP3 | P08254 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | FCER2 | P06734 | 4/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980436 | 0.85 | MMP8 (0.36) | ANPEPMMP8MMP1MMP2MMP3 | |
| SCHEMBL6984786 | 0.81 | MMP2 (0.32) | MMP8MMP1MMP2MMP3MMP13 | |
| Hydrochloric Acid SCHEMBL6986332 | 0.80 | MMP2 (0.32) | MMP8MMP1MMP2MMP3MMP13 | |
| SCHEMBL6985184 | 0.79 | MMP8 (0.40) | ANPEPMMP8MMP1MMP2MMP3 | |
| SCHEMBL6980958 | 0.79 | MMP1 (0.35) | MMP8MMP1MMP2MMP3ADAM17 | |
| SCHEMBL6983143 | 0.78 | ALDH1A1 (0.34) | MMP8MMP1MMP2MMP3TSHR | |
| SCHEMBL6981067 | 0.77 | CTSK (0.46) | — | |
| SCHEMBL6986934 | 0.77 | CTSK (0.44) | — | |
| SCHEMBL6986438 | 0.76 | CTSK (0.45) | — | |
| SCHEMBL6981614 | 0.76 | ADAM17 (0.39) | ANPEPMMP8MMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |