Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | KDM5A | P29375 | 2/20 | 0.47 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.47 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | TET3 | O43151 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM5C | P41229 | 1/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.40 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1735064 | 0.98 | KDM4E (0.49) | KDM4EKDM5AKDM3AJMJD1CKMT2A | |
| SCHEMBL13202841 | 0.85 | ALOX15 (0.42) | KDM4EKDM5AKDM3AJMJD1CKMT2A | |
| SCHEMBL750794 | 0.83 | ALDH1A1 (0.42) | KDM4EKMT2AMEN1ALOX15ALDH1A1 | |
| SCHEMBL2606740 | 0.82 | KDM4E (0.52) | KDM4EKDM5AKDM3AJMJD1CKMT2A | |
| SCHEMBL1489345 | 0.81 | KMT2A (0.46) | KDM4EKDM5AKDM3AJMJD1CKMT2A | |
| SCHEMBL6204024 | 0.81 | KMT2A (0.41) | KDM4EKMT2AMEN1ALOX15ALDH1A1 | |
| SCHEMBL29835033 | 0.81 | KMT2A (0.46) | KDM4EKDM5AKDM3AJMJD1CKMT2A | |
| Potassium Ion SCHEMBL6986954 | 0.80 | ALOX15 (0.39) | KDM4EKMT2AMEN1ALOX15TDP1 | |
| SCHEMBL2096921 | 0.79 | KDM4E (0.49) | KDM4EKDM5AKDM3AJMJD1CKMT2A | |
| SCHEMBL13060099 | 0.79 | KMT2A (0.39) | KDM4EKMT2AMEN1ALOX15TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1093367-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1079821-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2001-08-29 | — | — | EP | disclosed |
| EP-1093367-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-25 | — | — | EP | disclosed |
| EP-1079821-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999066925-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-29 | — | — | WO | disclosed |
| WO-1999059570-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-25 | — | — | WO | disclosed |