Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.46 |
| ▸ | DRD1 | P21728 | 8/20 | 0.46 |
| ▸ | DRD5 | P21918 | 8/20 | 0.46 |
| ▸ | DRD4 | P21917 | 6/20 | 0.46 |
| ▸ | DRD3 | P35462 | 6/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.39 |
| ▸ | EED | O75530 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6031009 | 0.88 | TSHR (0.42) | DRD2DRD1DRD5DRD4DRD3 | |
| SCHEMBL30561615 | 0.71 | KDM4E (0.44) | DRD2DRD3ADRA1AGRIN2DGRIN3B | |
| SCHEMBL25779928 | 0.71 | KDM4E (0.44) | DRD2DRD3ADRA1AGRIN2DGRIN3B | |
| SCHEMBL7136766 | 0.71 | PDPK1 (0.47) | DRD2DRD1DRD5DRD4DRD3 | |
| SCHEMBL19820931 | 0.68 | DRD1 (0.50) | DRD2DRD1DRD5DRD4DRD3 | |
| SCHEMBL4019735 | 0.67 | HPGD (0.34) | DRD1ADRA1AADRA1DADRA1B | |
| SCHEMBL712267 | 0.66 | — | — | |
| SCHEMBL11707272 | 0.65 | DRD2 (0.42) | DRD2DRD1DRD5DRD4DRD3 | |
| SCHEMBL238844 | 0.65 | — | — | |
| SCHEMBL25043599 | 0.64 | ADRA1A (0.37) | DRD2DRD1DRD5DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588858-B1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA NV (BE) | 2003-09-17 | — | — | EP | disclosed |
| CN-1142360-A | A method for preparing a medical composition conpaining imidazo[2,1-b][3] benzo azepine dericvants | YUAN ANLING (CN) | 1997-02-12 | — | — | CN | disclosed |
| US-5468743-A | Imidazo[2,1-b]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-11-21 | — | — | US | disclosed |
| EP-0588858-A1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-30 | — | — | EP | disclosed |
| WO-1992022551-A1 | IMIDAZO[2,1-b][3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-23 | — | — | WO | disclosed |
| EP-0518435-A1 | Imidazo[2,1-b][3]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |