Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 4/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988078 | 0.86 | SIGMAR1 (0.41) | PTAFRHRH1SIGMAR1KCNH2 | |
| SCHEMBL5060492 | 0.83 | HRH1 (0.47) | PTAFRHRH1KCNH2 | |
| SCHEMBL6991398 | 0.81 | PTAFR (0.38) | PTAFRHRH1 | |
| SCHEMBL5056412 | 0.74 | HRH1 (0.47) | PTAFRHRH1KCNH2 | |
| SCHEMBL27546512 | 0.72 | PTAFR (0.43) | PTAFRHRH1KCNH2 | |
| Water SCHEMBL5056711 | 0.72 | PTAFR (0.42) | PTAFRHRH1KCNH2 | |
| SCHEMBL6990285 | 0.72 | ADRA1A (0.41) | PTAFRHRH1SIGMAR1KCNH2 | |
| SCHEMBL9129563 | 0.70 | HRH1 (0.41) | PTAFRHRH1KCNH2 | |
| SCHEMBL27546513 | 0.69 | PTAFR (0.45) | PTAFRHRH1KCNH2 | |
| SCHEMBL6991281 | 0.68 | HRH1 (0.43) | PTAFRHRH1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588858-B1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA NV (BE) | 2003-09-17 | — | — | EP | disclosed |
| US-5468743-A | Imidazo[2,1-b]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-11-21 | — | — | US | disclosed |
| EP-0588858-A1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-30 | — | — | EP | disclosed |
| WO-1992022551-A1 | IMIDAZO[2,1-b][3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-23 | — | — | WO | disclosed |
| EP-0518435-A1 | Imidazo[2,1-b][3]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |