Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 7/20 | 0.73 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.73 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796877 | 0.88 | AVPR1A (0.71) | AVPR1AAVPR1BAVPR2MEN1KMT2A | |
| SCHEMBL6993669 | 0.87 | AVPR1A (0.79) | AVPR1AAVPR1BAVPR2MEN1KMT2A | |
| SCHEMBL6988983 | 0.85 | AVPR1A (0.79) | AVPR1AAVPR1BAVPR2MEN1KMT2A | |
| SCHEMBL6988528 | 0.84 | AVPR1A (1.00) | AVPR1AAVPR1BAVPR2 | |
| SCHEMBL8799494 | 0.84 | AVPR1A (0.65) | AVPR1AAVPR1BAVPR2MEN1KMT2A | |
| SCHEMBL7365160 | 0.82 | AVPR1A (0.68) | AVPR1AAVPR1BAVPR2MEN1KMT2A | |
| SCHEMBL8797050 | 0.81 | AVPR1A (0.59) | AVPR1AAVPR1BAVPR2MEN1KMT2A | |
| SCHEMBL6988098 | 0.80 | AVPR1A (0.74) | AVPR1AAVPR1BAVPR2MEN1KMT2A | |
| SCHEMBL6987073 | 0.80 | AVPR1A (0.80) | AVPR1AAVPR1BAVPR2KMT2AKDM4E | |
| SCHEMBL8883555 | 0.79 | AVPR1A (0.76) | AVPR1AAVPR1BAVPR2MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811008-B1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2003-10-01 | — | — | EP | claimed |
| US-5696112-A | TREATMENT OF CONGESTIVE HEART FAILURE, CORONARY VASOCONSTRICTION | AMERICAN CYANAMID COMPANY (US) | 1997-12-09 | — | — | US | claimed |
| US-5654297-A | CONGESTIVE HEART FAILURE, CARDIOVASCULAR DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1997-08-05 | — | — | US | claimed |
| WO-1996022294-A1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | claimed |
| EP-0811008-B1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2003-10-01 | — | — | EP | disclosed |
| US-5696112-A | TREATMENT OF CONGESTIVE HEART FAILURE, CORONARY VASOCONSTRICTION | AMERICAN CYANAMID COMPANY (US) | 1997-12-09 | — | — | US | disclosed |
| US-5654297-A | CONGESTIVE HEART FAILURE, CARDIOVASCULAR DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| WO-1996022294-A1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |