Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987190 | 0.77 | ALDH1A1 (0.54) | HTTSMN1; SMN2TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL6985367 | 0.67 | CYP19A1 (0.39) | NPC1L3MBTL1ALDH1A1CYP19A1MAPT | |
| SCHEMBL1878657 | 0.65 | CYP19A1 (0.55) | HTTL3MBTL1ALDH1A1HPGDCYP19A1 | |
| SCHEMBL11777239 | 0.64 | MPO (0.44) | HTTSMN1; SMN2TDP1TAAR1ALDH1A1 | |
| SCHEMBL9901553 | 0.63 | ALDH1A1 (0.50) | HTTSMN1; SMN2NPC1TDP1L3MBTL1 | |
| SCHEMBL22231717 | 0.63 | TAAR1 (0.45) | HTTSMN1; SMN2NPC1PPP1CATDP1 | |
| SCHEMBL6693208 | 0.63 | TAAR1 (0.45) | HTTSMN1; SMN2NPC1PPP1CATDP1 | |
| SCHEMBL31470103 | 0.62 | HTT (0.51) | HTTSMN1; SMN2NPC1PPP1CATDP1 | |
| SCHEMBL30023693 | 0.62 | MPO (0.41) | HTTSMN1; SMN2NPC1TDP1TAAR1 | |
| SCHEMBL805461 | 0.61 | TAAR1 (0.61) | HTTSMN1; SMN2TDP1TAAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303508-A1 | SUBSTITUTED 1-(4-AMINOPHENYL)INDOLES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006273-A1 | SUBSTITUTED 1-(4-AMINOPHENYL)INDOLES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2002-01-24 | — | — | WO | disclosed |