Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7216667 | 0.99 | CHRM1 (0.39) | CHRM1PTGS1PTGS2KDM4ETDP1 | |
| SCHEMBL6988257 | 0.82 | CHRM1 (0.59) | CHRM1 | |
| SCHEMBL6980919 | 0.80 | CHRM1 (0.48) | CHRM1 | |
| SCHEMBL6981312 | 0.77 | CHRM1 (0.43) | CHRM1 | |
| SCHEMBL6982103 | 0.76 | CHRM1 (0.38) | CHRM1 | |
| SCHEMBL6985817 | 0.76 | CHRM1 (0.35) | CHRM1 | |
| SCHEMBL6984398 | 0.76 | ALDH1A1 (0.42) | CHRM1MAOBMAPK1 | |
| Hydrochloric Acid SCHEMBL6987410 | 0.75 | CHRM1 (0.37) | CHRM1 | |
| Hydrochloric Acid SCHEMBL6987919 | 0.75 | ALDH1A1 (0.41) | CHRM1MAOBMAPK1 | |
| SCHEMBL6986177 | 0.74 | SLC6A4 (0.34) | CHRM1PTGS1PTGS2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189902-B1 | 7-OXO-2-AZABICYCLO[2.2.1]HEPTANES AS SELECTIVE MUSCARINIC RECEPTOR ANTAGONIST | LILLY CO ELI (US) | 2003-08-27 | — | — | EP | claimed |
| US-6559171-B1 | Muscarinic receptor modulators 7-oxo-2-azabicyclo(2.2.1)heptanes of formula (I) which are useful for the treatment of various diseases and conditions, for example, Alzheimer's disease, glaucoma, psychosis, | ELI LILLY AND COMPANY | 2003-05-06 | — | — | US | claimed |