Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1826507 | 1.00 | LMNA (0.44) | LMNAMAPK1ALDH1A1TSHRKMT2A | |
| SCHEMBL1826037 | 0.87 | LMNA (0.42) | LMNAMAPK1ALDH1A1TSHRKMT2A | |
| SCHEMBL1825895 | 0.86 | ALDH1A1 (0.43) | LMNAMAPK1ALDH1A1TSHRKMT2A | |
| SCHEMBL1828232 | 0.84 | LMNA (0.48) | LMNAMAPK1ALDH1A1TSHRKMT2A | |
| SCHEMBL1824500 | 0.83 | ALDH1A1 (0.42) | LMNAMAPK1ALDH1A1TSHRKMT2A | |
| SCHEMBL1825090 | 0.82 | LMNA (0.46) | LMNAMAPK1ALDH1A1KMT2AMEN1 | |
| SCHEMBL1825887 | 0.81 | ALDH1A1 (0.47) | LMNAMAPK1ALDH1A1KMT2AMEN1 | |
| SCHEMBL1826280 | 0.81 | LMNA (0.41) | LMNAMAPK1ALDH1A1TSHRKMT2A | |
| SCHEMBL1826318 | 0.81 | ALDH1A1 (0.46) | LMNAMAPK1ALDH1A1TSHRKMT2A | |
| SCHEMBL1824374 | 0.81 | CA1 (0.53) | LMNAMAPTATMP2RX7CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289980-A1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090100-A1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-11-29 | — | — | WO | disclosed |