Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CPS1 | P31327 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11619068 | 0.99 | KDM2B (0.57) | KDM2BALDH1A1RAB9AHSD11B1NPC1 | |
| SCHEMBL10638090 | 0.88 | KDM2B (0.47) | KDM2BALDH1A1RAB9AHSD11B1ABCG2 | |
| SCHEMBL10637499 | 0.85 | NPC1 (0.57) | ALDH1A1RAB9ANPC1ABCG2MEN1 | |
| SCHEMBL20524600 | 0.84 | CPS1 (0.68) | ALDH1A1HSD11B1MEN1KMT2ACPS1 | |
| SCHEMBL30323172 | 0.84 | CPS1 (0.68) | ALDH1A1HSD11B1MEN1KMT2ACPS1 | |
| Hydrochloric Acid SCHEMBL10640839 | 0.84 | NPC1 (0.55) | ALDH1A1RAB9ANPC1ABCG2MEN1 | |
| Hydrochloric Acid SCHEMBL30323144 | 0.83 | CPS1 (0.67) | ALDH1A1HSD11B1MEN1KMT2ACPS1 | |
| SCHEMBL11214722 | 0.82 | ALDH1A1 (0.49) | ALDH1A1RAB9ANPC1MEN1KMT2A | |
| Bromide SCHEMBL10640715 | 0.81 | ALDH1A1 (0.48) | ALDH1A1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL6712581 | 0.81 | HSD11B1 (0.63) | KDM2BALDH1A1RAB9AHSD11B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351936-A1 | ARYL PIPERIDINE AND PIPERAZINE DERIVATIVES AS INDUCERS OF LDL-RECEPTOR EXPRESSION | GLAXO GROUP LIMITED (GB) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002055496-A1 | ARYL PIPERIDINE AND PIPERAZINE DERIVATIVES AS INDUCERS OF LDL-RECEPTOR EXPRESSION | GLAXO GROUP LIMITED (GB) | 2002-07-18 | — | — | WO | disclosed |