Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2949559 | 0.78 | BCL2L1 (0.56) | BCL2L1 | |
| SCHEMBL25415098 | 0.78 | CA2 (0.46) | POLBDOT1LMAPTALDH1A1CA2 | |
| SCHEMBL25417577 | 0.76 | LMNA (0.44) | POLBMAPTTDP1ALDH1A1CA2 | |
| SCHEMBL18690053 | 0.72 | MAPT (0.39) | POLBMAPTALDH1A1CA2CA12 | |
| SCHEMBL21331190 | 0.72 | MAPT (0.50) | POLBDOT1LMAPTTDP1ALDH1A1 | |
| SCHEMBL1700214 | 0.71 | LMNA (0.51) | POLBMAPTALDH1A1CA2CA12 | |
| SCHEMBL523821 | 0.71 | LMNA (0.48) | POLBDOT1LMAPTALDH1A1CA2 | |
| SCHEMBL1700634 | 0.71 | CA2 (0.43) | POLBDOT1LMAPTTDP1ALDH1A1 | |
| SCHEMBL29482089 | 0.71 | LMNA (0.48) | POLBDOT1LMAPTALDH1A1CA2 | |
| SCHEMBL1700142 | 0.71 | CA2 (0.43) | POLBDOT1LMAPTTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318978-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | Abbott Laboratories (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024636-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2002-03-28 | — | — | WO | disclosed |