Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ECE1 | P42892 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27799074 | 0.84 | SMN1; SMN2 (0.40) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL10754839 | 0.81 | CYP1A2 (0.39) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL11668532 | 0.81 | ALDH1A1 (0.45) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL2771532 | 0.78 | RAB9A (0.38) | RAB9ANPC1MAPTSMN1; SMN2TDP1 | |
| SCHEMBL5230966 | 0.76 | SMN1; SMN2 (0.43) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL10655226 | 0.73 | HPGD (0.41) | RAB9AMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL27820098 | 0.72 | POLB (0.43) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL27575996 | 0.70 | KMT2A (0.48) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL27336449 | 0.69 | ALDH1A1 (0.47) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL27560937 | 0.68 | KDM4E (0.37) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289954-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1289972-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096303-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |
| WO-2001096323-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |