SCHEMBL6987694

SCHEMBL6987694

CC(=O)Nc1ccc2c(c1)C(OC(C)=O)CCC2

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 1/20 0.52
CHRM4 P08173 3/20 0.47
DRD2 P14416 3/20 0.47
HTR7 P34969 3/20 0.47
BAZ2B Q9UIF8 1/20 0.47
MAPT P10636 1/20 0.43
CHRNB2 P17787 1/20 0.43
CHRNA4 P43681 1/20 0.43
RAB9A P51151 2/20 0.42
RORC P51449 1/20 0.42
NPC1 O15118 2/20 0.42
CYP1A2 P05177 2/20 0.42
ADRA2A P08913 1/20 0.42
MAOA P21397 1/20 0.42
SLC6A2 P23975 1/20 0.42
HTR2C P28335 1/20 0.42
SLC6A4 P31645 1/20 0.42
HTR2B P41595 1/20 0.42
CYP2C19 P33261 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12256797 0.82 MTNR1A (0.55) MTNR1ABAZ2BMAPTCHRNB2CHRNA4
SCHEMBL11746560 0.81 MTNR1A (0.54) MTNR1ABAZ2BMAPTCHRNB2CHRNA4
SCHEMBL4455923 0.80 IDO1 (0.58) CHRM4DRD2HTR7
SCHEMBL30290988 0.80 IDO1 (0.58) CHRM4DRD2HTR7
Hydrochloric Acid SCHEMBL11748537 0.80 MTNR1A (0.53) MTNR1ABAZ2BCHRNB2CHRNA4RAB9A
SCHEMBL6811167 0.79 CHRM4 (0.50) CHRM4DRD2HTR7
SCHEMBL6812318 0.77 MTNR1A (0.67) MTNR1ABAZ2BMAPTCHRNB2CHRNA4
Hydrochloric Acid SCHEMBL11743654 0.76 MTNR1A (0.50) MTNR1ABAZ2BMAPTCHRNB2CHRNA4
SCHEMBL6817116 0.76 MTNR1A (0.59) MTNR1ABAZ2BMAPTCHRNB2CHRNA4
SCHEMBL2818102 0.76 PYGL (0.54) MTNR1ABAZ2BCHRNB2CHRNA4RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1345930-A2 PHARMACEUTICAL COMPOUNDS ELI LILLY AND COMPANY (US) 2003-09-24 EP disclosed
WO-2002050067-A2 PHARMACEUTICAL HETEROCYCLIC COMPOUNDS ELI LILLY AND COMPANY (US) 2002-06-27 WO disclosed