SCHEMBL6988016

SCHEMBL6988016

CC(C)(C)OC(=O)NCCOc1noc2cc(Cl)ccc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.49
KMT2A Q03164 2/20 0.49
IDO1 P14902 2/20 0.47
CYP1A1 P04798 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2B6 P20813 1/20 0.44
CYP2C19 P33261 1/20 0.44
CYP3A43 Q9HB55 1/20 0.44
CA12 O43570 2/20 0.42
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
CA9 Q16790 2/20 0.42
HPGD P15428 2/20 0.42
HTT P42858 2/20 0.42
KDM4E B2RXH2 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
MEN1 O00255 1/20 0.42
TP53 P04637 1/20 0.41
GLA P06280 1/20 0.41
MAPT P10636 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6989587 0.91 FAAH (0.49) ALDH1A1KMT2AIDO1CYP1A1CYP2D6
SCHEMBL6990733 0.88 CYP1A1 (0.45) ALDH1A1IDO1CYP1A1CYP2D6CYP2B6
SCHEMBL6988458 0.84 FAAH (0.51) IDO1CYP1A1CYP2D6CYP2B6CYP2C19
SCHEMBL6989190 0.81 NQO2 (0.48) ALDH1A1IDO1CYP1A1CYP2D6CYP2B6
SCHEMBL6993977 0.81 CA12 (0.46) ALDH1A1CYP1A1CYP2D6CYP2B6CYP2C19
SCHEMBL6992057 0.81 FAAH (0.53) IDO1CYP1A1CYP2D6CYP2B6CYP2C19
SCHEMBL6989160 0.80 IDO1 (0.44) ALDH1A1KMT2AIDO1CYP1A1CYP2D6
SCHEMBL6991027 0.80 STK17B (0.40) ALDH1A1KMT2AIDO1CYP1A1CYP2D6
SCHEMBL6987623 0.80 CA12 (0.45) ALDH1A1IDO1CYP1A1CYP2D6CYP2B6
SCHEMBL6991751 0.80 CA12 (0.50) ALDH1A1CYP1A1CYP2D6CYP2B6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0779281-B1 ISOXAZOLES SANKYO CO (JP) 2003-10-29 EP disclosed
US-6096771-A ISOXAZOLE DERIVATIVES EXHIBITING EXCELLENT TYPE B AND TYPE A MONOAMINE OXIDASE INHIBITORY ACTIVITIES, THEREFORE USEFUL FOR PREVENTING PARKINSON'S DISEASE, DEPRESSION AND ALZHEIMER'S DISEASE SANKYO COMPANY, LIMITED (JP) 2000-08-01 US disclosed
US-5965591-A MONOAMINE OXIDASE INHIBITOR; FOR PROPHYLAXIS AND TREATING PARKINSON'S DISEASE, DEPRESSION AND ALZHEIMER'S DISEASE SANKYO COMPANY, LIMITED (JP) 1999-10-12 US disclosed
EP-0779281-A1 ISOXAZOLES SANKYO COMPANY LIMITED (JP) 1997-06-18 EP disclosed