Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 6/20 | 0.52 |
| ▸ | PPARG | P37231 | 5/20 | 0.52 |
| ▸ | PPARD | Q03181 | 2/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | REN | P00797 | 2/20 | 0.47 |
| ▸ | CTSS | P25774 | 5/20 | 0.47 |
| ▸ | CTSK | P43235 | 4/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4671732 | 0.89 | PPARA (0.64) | PPARAPPARGPPARDMMP13CTSS | |
| SCHEMBL5142486 | 0.89 | PPARA (0.64) | PPARAPPARGPPARDMMP13CTSS | |
| SCHEMBL4671738 | 0.89 | PPARA (0.64) | PPARAPPARGPPARDMMP13CTSS | |
| SCHEMBL2948733 | 0.87 | NFKB1 (0.53) | PPARAPPARGPPARDMMP13CTSS | |
| SCHEMBL2951876 | 0.87 | NFKB1 (0.53) | PPARAPPARGPPARDMMP13CTSS | |
| SCHEMBL4673130 | 0.86 | MMP13 (0.49) | PPARAPPARGPPARDMMP13CTSS | |
| SCHEMBL4673137 | 0.86 | MMP13 (0.49) | PPARAPPARGPPARDMMP13CTSS | |
| SCHEMBL6578569 | 0.85 | PPARA (0.50) | PPARAPPARGPPARDMMP13CTSS | |
| SCHEMBL7490297 | 0.85 | PPARA (0.50) | PPARAPPARGPPARDMMP13CTSS | |
| SCHEMBL7494588 | 0.85 | PPARA (0.50) | PPARAPPARGPPARDMMP13CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318978-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | Abbott Laboratories (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024636-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2002-03-28 | — | — | WO | disclosed |