Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.43 |
| ▸ | CTSB | P07858 | 4/20 | 0.40 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6751806 | 0.90 | CTSL (0.54) | CTSLCTSBCTSSCTSKGRIA1 | |
| SCHEMBL6747644 | 0.90 | CTSL (0.42) | CTSLCTSBLNPEPCA1CA2 | |
| SCHEMBL6747731 | 0.90 | CTSL (0.42) | CTSLCTSBLNPEPCA1CA2 | |
| SCHEMBL6984396 | 0.89 | CTSL (0.43) | CTSLCTSBLNPEPCTSSCTSK | |
| SCHEMBL6749622 | 0.89 | CTSB (0.42) | CTSLCTSBCTSSCTSKACE2 | |
| SCHEMBL6749679 | 0.89 | CTSL (0.42) | CTSLCTSBLNPEPCA1CA2 | |
| SCHEMBL6751310 | 0.89 | CTSB (0.51) | CTSLCTSBLNPEPCA1CA2 | |
| SCHEMBL6988426 | 0.88 | CTSL (0.41) | CTSLCTSBLNPEPCA1CA2 | |
| SCHEMBL6747766 | 0.87 | CTSL (0.40) | CTSLCTSBLNPEPCA1CA2 | |
| SCHEMBL6749598 | 0.86 | USP30 (0.44) | CTSLLNPEPERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362042-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057249-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |