Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982406 | 0.89 | LMNA (0.47) | CYP2C19CYP1A2CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL6989621 | 0.89 | HPGD (0.44) | CYP2C19CYP1A2CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL1168605 | 0.84 | CYP1A2 (0.56) | CYP2C19CYP1A2CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL6986149 | 0.83 | GAA (0.45) | CYP2C19CYP1A2CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL6986623 | 0.80 | KMT2A (0.44) | ALDH1A1MAPTHTTSMN1; SMN2HPGD | |
| SCHEMBL6986984 | 0.79 | KMT2A (0.57) | CYP2C19CYP1A2CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL7139639 | 0.79 | KMT2A (0.48) | ALDH1A1MAPTHTTSMN1; SMN2HPGD | |
| SCHEMBL6992491 | 0.78 | KMT2A (0.45) | ALDH1A1MAPTHTTSMN1; SMN2HPGD | |
| SCHEMBL6989701 | 0.78 | KMT2A (0.41) | CYP2C19CYP1A2CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL6984524 | 0.77 | KMT2A (0.45) | CYP2C19CYP1A2CYP3A4CYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341779-A2 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | Wyeth (US) | 2003-09-10 | — | — | EP | claimed |
| WO-2002057252-A2 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH (US) | 2002-07-25 | — | — | WO | claimed |