Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.37 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | EDNRB | P24530 | 1/20 | 0.31 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | GPR183 | P32249 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7616 | 0.81 | LPAR1 (0.47) | LPAR1LPAR2LPAR3CYP2C9FFAR4 | |
| SCHEMBL6575 | 0.78 | LPAR1 (0.39) | LPAR1LPAR2LPAR3CYP2C9TDP1 | |
| SCHEMBL1300 | 0.71 | CYP1A2 (0.40) | CYP1A2CYP3A4CYP2C9CYP2C19TDP1 | |
| SCHEMBL7556 | 0.70 | MEN1 (0.36) | LPAR1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7557 | 0.70 | MEN1 (0.36) | LPAR1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1683 | 0.69 | CYP1A2 (0.43) | CYP1A2CYP3A4CYP2C9CYP2C19TDP1 | |
| SCHEMBL1458 | 0.69 | MAOB (0.40) | LPAR1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1406 | 0.68 | LPAR1 (0.40) | LPAR1LPAR2LPAR3CYP2C9ALDH1A1 | |
| SCHEMBL22257228 | 0.68 | ALDH1A1 (0.44) | LPAR1LPAR3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL18597812 | 0.68 | CYP1A2 (0.44) | CYP1A2CYP3A4CYP2C9CYP2C19TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |