Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 12/20 | 0.59 |
| ▸ | AXL | P30530 | 13/20 | 0.59 |
| ▸ | MST1R | Q04912 | 2/20 | 0.58 |
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.56 |
| ▸ | FER | P16591 | 1/20 | 0.56 |
| ▸ | CDK8 | P49336 | 1/20 | 0.56 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.56 |
| ▸ | MERTK | Q12866 | 1/20 | 0.56 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168502 | 0.96 | MET (0.61) | METAXLMST1RAURKAABL1 | |
| Trifluoroacetic Acid SCHEMBL168241 | 0.91 | AXL (0.66) | METAXLMST1RAURKAABL1 | |
| SCHEMBL167638 | 0.85 | AXL (0.69) | METAXLMST1RAURKAABL1 | |
| SCHEMBL168721 | 0.85 | MET (0.62) | METAXLKDRKITFLT3 | |
| Trifluoroacetic Acid SCHEMBL705178 | 0.85 | AXL (0.64) | METAXLMST1RAURKAABL1 | |
| SCHEMBL168132 | 0.84 | MET (0.71) | METAXLMST1RAURKAABL1 | |
| Trifluoroacetic Acid SCHEMBL698181 | 0.84 | MET (0.63) | METAXLMST1RAURKAABL1 | |
| Trifluoroacetic Acid SCHEMBL696273 | 0.83 | AXL (0.58) | METAXLMST1RAURKAABL1 | |
| Trifluoroacetic Acid SCHEMBL167604 | 0.81 | AXL (0.64) | METAXLMST1RAURKAABL1 | |
| Trifluoroacetic Acid SCHEMBL696882 | 0.80 | AXL (0.64) | METAXLMST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609091-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2014-11-26 | — | — | EP | disclosed |
| EP-2423208-A1 | Pharmaceutically active compounds as Axl inhibitors | Lead Discovery Center GmbH (DE) | 2012-02-29 | — | — | EP | disclosed |