Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 6/20 | 0.58 |
| ▸ | MET | P08581 | 16/20 | 0.57 |
| ▸ | MST1R | Q04912 | 2/20 | 0.57 |
| ▸ | KDR | P35968 | 5/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.56 |
| ▸ | JAK1 | P23458 | 1/20 | 0.56 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168401 | 0.95 | AXL (0.61) | AXLMETMST1RKDRKIT | |
| Trifluoroacetic Acid SCHEMBL697610 | 0.89 | MET (0.59) | AXLMETMST1RKDRKIT | |
| Trifluoroacetic Acid SCHEMBL695927 | 0.87 | MET (0.59) | AXLMETMST1RKDRKIT | |
| Trifluoroacetic Acid SCHEMBL698181 | 0.85 | MET (0.63) | AXLMETMST1RKDRKIT | |
| SCHEMBL168714 | 0.85 | MET (0.63) | AXLMETMST1RKDRKIT | |
| Trifluoroacetic Acid SCHEMBL695728 | 0.84 | MET (0.61) | AXLMETMST1RKDRKIT | |
| Trifluoroacetic Acid SCHEMBL168241 | 0.84 | AXL (0.66) | AXLMETMST1RKDRKIT | |
| SCHEMBL167642 | 0.83 | MET (0.62) | AXLMETMST1RKDRKIT | |
| Trifluoroacetic Acid SCHEMBL705178 | 0.83 | AXL (0.64) | AXLMETMST1RKDRKIT | |
| Trifluoroacetic Acid SCHEMBL698912 | 0.83 | MET (0.59) | AXLMETMST1RKDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609091-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2014-11-26 | — | — | EP | disclosed |
| EP-2423208-A1 | Pharmaceutically active compounds as Axl inhibitors | Lead Discovery Center GmbH (DE) | 2012-02-29 | — | — | EP | disclosed |