SCHEMBL6989127

SCHEMBL6989127

Cc1ccc2onc(SCCN)c2c1

nearest known ligand 0.46

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.46
TP53 P04637 6/20 0.38
LMNA P02545 5/20 0.38
TDP1 Q9NUW8 1/20 0.36
HTR2C P28335 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
THRB P10828 1/20 0.34
POLB P06746 2/20 0.34
ACHE P22303 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6996364 0.98 MAPT (0.44) MAPTTP53LMNATDP1HTR2C
SCHEMBL5618224 0.81 FAAH (0.39) MAPTLMNATHRB
SCHEMBL5617754 0.81 MPO (0.37) MAPTLMNATDP1POLB
SCHEMBL5617936 0.81 DYRK1A (0.46) MAPTHTR2CPOLBACHE
Hydrochloric Acid SCHEMBL6990415 0.80 FAAH (0.38) MAPTLMNATHRB
Hydrochloric Acid SCHEMBL6992021 0.80 MPO (0.36) MAPTTDP1HTR2CPOLB
Hydrochloric Acid SCHEMBL6985329 0.80 DYRK1A (0.45) MAPTTDP1HTR2CTHRBPOLB
SCHEMBL6994467 0.79 CA12 (0.46) MAPTLMNA
SCHEMBL6993891 0.76 IDO1 (0.36) L3MBTL1
Hydrochloric Acid SCHEMBL6986907 0.75 IDO1 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0779281-B1 ISOXAZOLES SANKYO CO (JP) 2003-10-29 EP claimed
US-6096771-A ISOXAZOLE DERIVATIVES EXHIBITING EXCELLENT TYPE B AND TYPE A MONOAMINE OXIDASE INHIBITORY ACTIVITIES, THEREFORE USEFUL FOR PREVENTING PARKINSON'S DISEASE, DEPRESSION AND ALZHEIMER'S DISEASE SANKYO COMPANY, LIMITED (JP) 2000-08-01 US claimed
US-5965591-A MONOAMINE OXIDASE INHIBITOR; FOR PROPHYLAXIS AND TREATING PARKINSON'S DISEASE, DEPRESSION AND ALZHEIMER'S DISEASE SANKYO COMPANY, LIMITED (JP) 1999-10-12 US claimed
EP-0779281-A1 ISOXAZOLES SANKYO COMPANY LIMITED (JP) 1997-06-18 EP claimed
EP-0779281-B1 ISOXAZOLES SANKYO CO (JP) 2003-10-29 EP disclosed
US-6096771-A ISOXAZOLE DERIVATIVES EXHIBITING EXCELLENT TYPE B AND TYPE A MONOAMINE OXIDASE INHIBITORY ACTIVITIES, THEREFORE USEFUL FOR PREVENTING PARKINSON'S DISEASE, DEPRESSION AND ALZHEIMER'S DISEASE SANKYO COMPANY, LIMITED (JP) 2000-08-01 US disclosed
US-5965591-A MONOAMINE OXIDASE INHIBITOR; FOR PROPHYLAXIS AND TREATING PARKINSON'S DISEASE, DEPRESSION AND ALZHEIMER'S DISEASE SANKYO COMPANY, LIMITED (JP) 1999-10-12 US disclosed
EP-0779281-A1 ISOXAZOLES SANKYO COMPANY LIMITED (JP) 1997-06-18 EP disclosed