SCHEMBL6989180

SCHEMBL6989180

COc1cccc2onc(SCCN)c12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 2/20 0.43
ALDH1A1 P00352 4/20 0.39
MAPT P10636 2/20 0.39
HTR2A P28223 1/20 0.36
DDAH1 O94760 1/20 0.35
ADRA2C P18825 1/20 0.35
MAOA P21397 1/20 0.35
AR P10275 3/20 0.35
KDM4E B2RXH2 3/20 0.35
HPGD P15428 3/20 0.35
NQO1 P15559 1/20 0.35
TP53 P04637 1/20 0.35
CYP3A4 P08684 1/20 0.35
HSD17B10 Q99714 1/20 0.35
SGMS1 Q86VZ5 1/20 0.35
SGMS2 Q8NHU3 1/20 0.35
TAAR1 Q96RJ0 1/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
EDNRA P25101 1/20 0.34
NPC1 O15118 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6989219 0.81 DDAH1 (0.38) DDAH1ADRA2CCYP3A4SGMS1SGMS2
SCHEMBL6991893 0.80 DDAH1 (0.39) DDAH1ADRA2CCYP3A4HSD17B10LMNA
SCHEMBL6985525 0.80 DDAH1 (0.39) DDAH1ADRA2CARTP53CYP3A4
SCHEMBL6985579 0.78 DDAH1 (0.38) ALDH1A1MAPTDDAH1ADRA2CCYP3A4
Hydrochloric Acid SCHEMBL6988422 0.77 ALDH1A1 (0.38) ALDH1A1MAPTHTR2AMAOAKDM4E
SCHEMBL6990277 0.73 KCNA5 (0.43) KCNA5HTR2AMAOAKDM4ENQO1
SCHEMBL1781983 0.72 KDR (0.50) KCNA5ALDH1A1MAPTMAOAEDNRA
Hydrochloric Acid SCHEMBL6994636 0.72 KCNA5 (0.43) KCNA5HTR2AMAOAKDM4ENQO1
SCHEMBL6993891 0.71 IDO1 (0.36) DDAH1ADRA2C
SCHEMBL6989239 0.71 KCNA5 (0.42) KCNA5ALDH1A1MAPTHTR2AMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0779281-B1 ISOXAZOLES SANKYO CO (JP) 2003-10-29 EP claimed
EP-0779281-A1 ISOXAZOLES SANKYO COMPANY LIMITED (JP) 1997-06-18 EP claimed
EP-0779281-B1 ISOXAZOLES SANKYO CO (JP) 2003-10-29 EP disclosed
US-6096771-A ISOXAZOLE DERIVATIVES EXHIBITING EXCELLENT TYPE B AND TYPE A MONOAMINE OXIDASE INHIBITORY ACTIVITIES, THEREFORE USEFUL FOR PREVENTING PARKINSON'S DISEASE, DEPRESSION AND ALZHEIMER'S DISEASE SANKYO COMPANY, LIMITED (JP) 2000-08-01 US disclosed
US-5965591-A MONOAMINE OXIDASE INHIBITOR; FOR PROPHYLAXIS AND TREATING PARKINSON'S DISEASE, DEPRESSION AND ALZHEIMER'S DISEASE SANKYO COMPANY, LIMITED (JP) 1999-10-12 US disclosed
EP-0779281-A1 ISOXAZOLES SANKYO COMPANY LIMITED (JP) 1997-06-18 EP disclosed