Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 7/20 | 0.56 |
| ▸ | AVPR1B | P47901 | 7/20 | 0.56 |
| ▸ | AVPR2 | P30518 | 12/20 | 0.46 |
| ▸ | OXTR | P30559 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987460 | 0.86 | AVPR1A (0.71) | AVPR1AAVPR1BAVPR2OXTRPOLB | |
| SCHEMBL9054176 | 0.81 | AVPR1A (0.64) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL6989377 | 0.77 | AVPR1A (0.55) | AVPR1AAVPR1BAVPR2ALDH1A1 | |
| SCHEMBL6988392 | 0.77 | AVPR1A (0.64) | AVPR1AAVPR1BAVPR2 | |
| SCHEMBL6986830 | 0.76 | AVPR1A (0.75) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL6986447 | 0.75 | AVPR1A (0.71) | AVPR1AAVPR1BAVPR2 | |
| SCHEMBL6988324 | 0.73 | AVPR1A (0.60) | AVPR1AAVPR1BAVPR2OXTRPOLB | |
| SCHEMBL5233630 | 0.73 | HCAR3 (0.56) | ALDH1A1 | |
| SCHEMBL6991954 | 0.73 | AVPR1A (0.65) | AVPR1AAVPR1BAVPR2POLBALDH1A1 | |
| SCHEMBL5231380 | 0.72 | NPC1 (0.54) | ALDH1A1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811008-B1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2003-10-01 | — | — | EP | disclosed |
| US-5654297-A | CONGESTIVE HEART FAILURE, CARDIOVASCULAR DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| WO-1997008184-A1 | METHODS AND COMPOSITIONS INCLUDING DNA DAMAGING AGENTS AND TYROSINE KINASE INHIBITORS OR ACTIVATORS | ARCH DEVELOPMENT CORPORATION (US) | 1997-03-06 | — | — | WO | disclosed |
| WO-1996022294-A1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |