Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 12/20 | 0.66 |
| ▸ | AVPR2 | P30518 | 12/20 | 0.66 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.54 |
| ▸ | OXTR | P30559 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984084 | 0.90 | AVPR2 (0.81) | AVPR1AAVPR2OXTR | |
| SCHEMBL6991947 | 0.86 | AVPR1A (0.65) | AVPR1AAVPR2AVPR1BOXTR | |
| SCHEMBL6995626 | 0.86 | AVPR1A (0.57) | AVPR1AAVPR2AVPR1BTP53MAPT | |
| SCHEMBL6986446 | 0.84 | AVPR2 (0.71) | AVPR1AAVPR2AVPR1BOXTR | |
| SCHEMBL6993624 | 0.82 | AVPR1A (0.66) | AVPR1AAVPR2AVPR1BOXTR | |
| SCHEMBL6989953 | 0.80 | AVPR2 (0.62) | AVPR1AAVPR2AVPR1BOXTRTP53 | |
| SCHEMBL8797804 | 0.80 | AVPR1A (1.00) | AVPR1AAVPR2AVPR1BOXTR | |
| SCHEMBL6989325 | 0.79 | AVPR1A (0.64) | AVPR1AAVPR2AVPR1BOXTRMAPT | |
| SCHEMBL6993625 | 0.78 | AVPR1A (0.63) | AVPR1AAVPR2AVPR1BOXTRTP53 | |
| SCHEMBL6991644 | 0.78 | AVPR1A (0.73) | AVPR1AAVPR2AVPR1BOXTRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811008-B1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2003-10-01 | — | — | EP | claimed |
| US-5696112-A | TREATMENT OF CONGESTIVE HEART FAILURE, CORONARY VASOCONSTRICTION | AMERICAN CYANAMID COMPANY (US) | 1997-12-09 | — | — | US | claimed |
| US-5654297-A | CONGESTIVE HEART FAILURE, CARDIOVASCULAR DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1997-08-05 | — | — | US | claimed |
| WO-1996022294-A1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | claimed |
| EP-0811008-B1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2003-10-01 | — | — | EP | disclosed |