Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989538 | 1.00 | MTNR1B (0.49) | MTNR1BALDH1A1MAPTHPGDTSHR | |
| SCHEMBL7566815 | 0.86 | PARP1 (0.48) | SMN1; SMN2NPC1RAB9ANPSR1L3MBTL1 | |
| SCHEMBL6991074 | 0.86 | PARP1 (0.48) | SMN1; SMN2NPC1RAB9ANPSR1L3MBTL1 | |
| SCHEMBL6991071 | 0.86 | PARP1 (0.48) | SMN1; SMN2NPC1RAB9ANPSR1L3MBTL1 | |
| SCHEMBL29380426 | 0.86 | PARP1 (0.48) | SMN1; SMN2NPC1RAB9ANPSR1L3MBTL1 | |
| SCHEMBL7566816 | 0.86 | PARP1 (0.48) | SMN1; SMN2NPC1RAB9ANPSR1L3MBTL1 | |
| SCHEMBL7241406 | 0.83 | MTNR1B (0.48) | MTNR1BALDH1A1MAPTHPGDTSHR | |
| SCHEMBL7241403 | 0.83 | MTNR1B (0.48) | MTNR1BALDH1A1MAPTHPGDTSHR | |
| SCHEMBL5463056 | 0.79 | TRPV1 (0.72) | MTNR1BALDH1A1MAPTHPGDTSHR | |
| SCHEMBL5464723 | 0.79 | MTNR1B (0.61) | MTNR1BTRPV1MTNR1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649626-B1 | Stimulants of gamma -aminobutyric acid receptors; psychological disorders | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2003-11-18 | — | — | US | disclosed |
| EP-1224182-B1 | N-SUBSTITUTED 1-(BUTYROLACTONE)-ISOQUINOLINES FOR TREATING NERVOUS DISORDERS | CENTRE NAT RECH SCIENT (FR) | 2003-07-16 | — | — | EP | disclosed |