SCHEMBL6989541

SCHEMBL6989541

NC(=O)NC(=O)c1c(F)cccc1F

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 1/20 0.53
JAK1 P23458 1/20 0.53
TYK2 P29597 1/20 0.53
HTT P42858 1/20 0.53
NOD2 Q9HC29 1/20 0.53
CES2 O00748 1/20 0.52
CES1 P23141 1/20 0.52
MEN1 O00255 3/20 0.52
KMT2A Q03164 3/20 0.52
ITGB2 P05107 1/20 0.50
ICAM1 P05362 1/20 0.50
ITGAL P20701 1/20 0.50
PPIA P62937 1/20 0.49
LMNA P02545 1/20 0.49
RAB9A P51151 4/20 0.46
NPC1 O15118 3/20 0.46
ATM Q13315 1/20 0.44
TP53 P04637 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11499405 0.87 GAA (0.59) JAK2JAK1TYK2KMT2AITGB2
SCHEMBL31259499 0.87 CES2 (0.61) JAK2JAK1TYK2HTTNOD2
SCHEMBL5529438 0.84 ALDH1A1 (0.53) JAK2JAK1TYK2HTTNOD2
SCHEMBL27675595 0.83 KMT2A (0.62) MEN1KMT2ARAB9ANPC1ATM
Hydrochloric Acid SCHEMBL8390632 0.82 KMT2A (0.47) JAK2JAK1TYK2HTTNOD2
SCHEMBL11099551 0.81 CES2 (0.54) JAK2JAK1TYK2HTTNOD2
SCHEMBL11237942 0.79 CES2 (0.52) JAK2JAK1TYK2HTTNOD2
SCHEMBL13328951 0.79 CES2 (0.52) JAK2JAK1TYK2HTTNOD2
Hydrochloric Acid SCHEMBL11237947 0.79 CES2 (0.52) JAK2JAK1TYK2HTTNOD2
SCHEMBL10772687 0.79 CES2 (0.57) HTTCES2CES1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115108974-A 2, 6-difluorobenzoylurea derivative and preparation method and application thereof 重庆医药高等专科学校 2022-09-27 CN claimed
CN-109444291-A A kind of detection method of content of 1- (4- chlorphenyl) -3- (2,6- difluoro benzoyl) urea 湖北回盛生物科技有限公司 2019-03-08 CN claimed
CN-106829509-A One kind analysis the axle auto-sequencing palletizing apparatus of standard specimen three and its method of work 徐州工程学院 2017-06-13 CN claimed
US-9320270-B2 Method of field application of natural pesticides with reduced toxicity and high efficacy by means of microencapsulation FMC CORPORATION 2016-04-26 US claimed
WO-1999016316-A1 ENHANCEMENT OF SEED YIELD OF SOYBEANS BY A SUBSTITUTED BENZOYL UREA UNIROYAL CHEMICAL COMPANY, INC. (US) 1999-04-08 WO claimed
US-5321049-A Pesticides DOWELANCO (US) 1994-06-14 US claimed
EP-0242322-B1 PHENYLUREAS SANDOZ AG (CH) 1992-12-16 EP claimed
US-5096710-A Cockroaches, juvenile hormone or chitin synthesis inhibitor, dextrin, plant oil SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-03-17 US claimed
EP-0349999-A2 Process for preparing highly active water-dispersible pesticides DOWELANCO (US) 1990-01-10 EP claimed
CN-119924331-A Pesticide suspending agent composition and preparation method thereof 中科生物技术(山东)有限公司 2025-05-06 CN disclosed
WO-2022264064-A1 NOVALURON WATER DISPERSIBLE SOLID COMPOSITION ADAMA MAKHTESHIM LTD. (IL) 2022-12-22 WO disclosed
CN-115108974-A 2, 6-difluorobenzoylurea derivative and preparation method and application thereof 重庆医药高等专科学校 2022-09-27 CN disclosed
CN-115108974-A 2, 6-difluorobenzoylurea derivative and preparation method and application thereof 重庆医药高等专科学校 2022-09-27 CN disclosed
CN-115108974-A 2, 6-difluorobenzoylurea derivative and preparation method and application thereof 重庆医药高等专科学校 2022-09-27 CN disclosed
WO-2002018339-A2 COMPOUNDS USEFUL AS INSECTICIDES, COMPOUNDS USEFUL AS ACARICIDES, AND PROCESSES TO USE AND MAKE SAME DOW AGROSCIENCES LLC (US) 2002-03-07 WO disclosed
US-5420163-A Insecticides or miticides CIBA-GEIGY (US) 1995-05-30 US disclosed
EP-0242322-B1 PHENYLUREAS SANDOZ AG (CH) 1992-12-16 EP disclosed
EP-0387946-A1 Process for preparing carbamates and intermediates therein SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1990-09-19 EP disclosed
EP-0198601-A2 Pesticidal alpha-cyanobenzyl phenyl benzoyl urea compounds RHONE-POULENC NEDERLAND B.V. (NL) 1986-10-22 EP disclosed
EP-0033231-B1 INSECTICIDAL COMPOSITIONS CONTAINING 2,6-DIHALOBENZOYLUREA DERIVATIVES ELI LILLY AND COMPANY (US) 1984-06-13 EP disclosed